Peripheral modulation of pain in conscions guinea pigs: effect of morphine nalorphine and clonidine
Braz. j. med. biol. res
;
21(3): 577-83, Mar. 1988. ilus
Article
in English
| LILACS
| ID: lil-60268
ABSTRACT
Morphine and nalorphine were shown to have a peripheral effect on conscious guinea pigs, producing a decrease in the vocalization response to noxious electrical stimulation. Naloxone antagonized the effect of morphine and nalorphine. Locally administered clonidine had a peripheral effect on conscious guinea pigs, producing a decrease in the vocalization response to noxious electrical stimulation. The peripheral analgesia of clonidine was antagonized by yohimbine and naloxone. The analgesic effect clonidine was 250-300 times more potent than that of lidocaine. It is suggested that alfa2-adrenergic receptor agonists may active enkephalin-like substances released at the peripheral level
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Index:
LILACS (Americas)
Main subject:
Vocalization, Animal
/
Pain Measurement
/
Clonidine
/
Dose-Response Relationship, Drug
/
Electric Stimulation
/
Analgesia
/
Injections, Subcutaneous
/
Morphine
/
Nalorphine
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1988
Type:
Article
/
Project document
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