Evidence for a role of beta-endorphin in activity of nigrostriatal neurons in the rat

Lebrun, I; Lebrun, F. L. A. S; Aizenstein, Moacyr Luiz

Lebrun, I; Lebrun, F. L. A. S; Aizenstein, Moacyr Luiz.

Braz. j. med. biol. res ; 21(3): 645-7, Mar. 1988. tab

Article in English | LILACS | ID: lil-60271

ABSTRACT

ABSTRACT

The effects of icv administration of ß-endorphin on secretory activity of dopaminergic neurons is described. Homovanillic and dihydroxyphenyl acetic acid levels in cerebrospinal fluid and extracts of brain tissue were determined after administration of ß-endorphin to animals pretreated or not with saloxone. The results suggest that ß-endorphin interferes with formation of dopaminergic metabolites by acting on opioid receptors

Subject(s)

Rats; Animals; 3,4-Dihydroxyphenylacetic Acid/cerebrospinal fluid; beta-Endorphin/physiology; Corpus Striatum/metabolism; Homovanillic Acid/cerebrospinal fluid; Substantia Nigra/metabolism; Dopamine/metabolism; Naloxone/therapeutic use; Neurons/physiology

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Index: LILACS (Americas) Main subject: 3,4-Dihydroxyphenylacetic Acid / Substantia Nigra / Beta-Endorphin / Corpus Striatum / Homovanillic Acid Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1988 Type: Article / Congress and conference

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