Protein-energy malnutrition increases teratogenicity of hypervitaminosis A in rats
Braz. j. med. biol. res
;
21(3): 659-62, Mar. 1988. tab
Article
in English
| LILACS
| ID: lil-60275
ABSTRACT
The present study was designed to investigate the embryofetotoxicity of vitamin A in protein-energy malnourished animals. Retinyl palmitate (66, 99 and 132 mg/kg) suspendend in corn oil was given by gavage to well-nourished and malnourished rats from gestational days 8 to 10 and cesarean sections were performed on day 20. All fetuses were weighed and examined for malformations before being prepared for skeletal evaluation. The proportion of malformed fetuses was higher in the malnourished group at each one of the three dose levels. The data indicate that malnourished animals are more susceptible to the toxic effects of retinyl esters
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Index:
LILACS (Americas)
Main subject:
Congenital Abnormalities
/
Tretinoin
/
Vitamin A
/
Hypervitaminosis A
/
Protein-Energy Malnutrition
Limits:
Animals
/
Pregnancy
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1988
Type:
Article
/
Congress and conference
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