Meta-análise Cochrane: teicoplanina versus vancomicina para infecções suspeitas ou confirmadas / Cochrane meta-analysis: teicoplanin versus vancomycin for proven or suspected infection
Einstein (Säo Paulo)
;
9(3)july-sept. 2011. tab, ilus
Article
in English, Portuguese
| LILACS
| ID: lil-604947
RESUMO
Objective:
To compare efficacy and safety of vancomycin versus teicoplanin in patients with proven or suspected infection.Methods:
Data Sources Cochrane Renal Group's Specialized Register, CENTRAL, MEDLINE, EMBASE, nephrology textbooks and review articles. Inclusion criteria Randomized controlled trials in any language comparing teicoplanin to vancomycin for patients with proven or suspected infection. Data extraction Two authors independently evaluated methodological quality and extracted data. Study investigators were contacted for unpublished information. A random effect model was used to estimate the pooled risk ratio (RR) with 95% confidence interval (CI).Results:
A total of 24 studies (2,610 patients) were included. The drugs had similar rates of clinical cure (RR 1.03; 95%CI 0.98-1.08), microbiological cure (RR 0.98; 95%CI 0.93-1.03) and mortality (RR 1.02; 95%CI 0.79-1.30). Teicoplanin had lower rates of skin rash (RR 0.57; 95%CI 0.35-0.92), red man syndrome (RR 0.21; 95%CI 0.08-0.59) and total adverse events (RR 0.73; 95%CI 0.53-1.00). Teicoplanin reduced the risk of nephrotoxicity (RR 0.66; 95%CI 0.48-0.90). This effect was consistent for patients receiving aminoglycosides (RR 0.51; 95%CI 0.30-0.88) or having vancomycin doses corrected by serum levels (RR 0.22; 95%CI 0.10-0.52). There were no cases of acute kidney injury needing dialysis.Limitations:
Studies lacked a standardized definition for nephrotoxicity.Conclusions:
Teicoplanin and vancomycin are equally effective; however the incidence of nephrotoxicity and other adverse events was lower with teicoplanin. It may be reasonable to consider teicoplanin for patients at higher risk for acute kidney injury.
Agentes antibacterianos/efeitos adversos; Agentes antibacterianos/uso terapêutico; Anti-bacterial agents/adverse effects; Anti-bacterial agents/therapeutic use; Drug eruptions/etiology; Erupção por droga/etiologia; Kidney/drug effects; Rim/efeitos de droga; Teicoplanin/adverse effects; Teicoplanin/therapeutic use; Teicoplanina/efeitos adversos; Teicoplanina/uso terapêutico; Vancomicina/efeitos adversos; Vancomicina/uso terapêutico; Vancomycin/adverse effects; Vancomycin/therapeutic use
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vancomycin
/
Teicoplanin
/
Drug Eruptions
/
Kidney
/
Anti-Bacterial Agents
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Prognostic study
/
Systematic reviews
Language:
English
/
Portuguese
Journal:
Einstein (Säo Paulo)
Journal subject:
Medicine
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital Israelita Albert Einstein/BR
/
Hospital do Coração/BR
/
Universidade da Região de Joinville/BR
/
Universidade de São Paulo/BR
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