Markers of insulin resistance and sedentary lifestyle are predictors of preeclampsia in women with adverse obstetric results
Braz. j. med. biol. res
;
44(12): 1285-1290, Dec. 2011. ilus, tab
Article
in English
| LILACS
| ID: lil-606540
ABSTRACT
Some thrombophilias and severe preeclampsia may increase the risk for preterm deliveries and fetal death due to placental insufficiency. Our objective was to evaluate clinical and laboratory data as predictors of preeclampsia in a population of mothers with 3rd trimester fetal losses or preterm deliveries. In a longitudinal retrospective study, 54 consecutive women (age range 16 to 39 years) with normotensive pregnancies were compared to 79 consecutive women with preeclampsia (age range 16 to 43 years). Weight accrual rate (WAR) was arbitrarily defined as weight gain from age 18 years to the beginning of pregnancy divided by elapsed years. Independent predictors of preeclampsia were past history of oligomenorrhea, WAR >0.8 kg/years, pre-pregnancy or 1st trimester triglyceridemia >150 mg/dL, and elevated acanthosis nigricans in the neck. In a multivariate logistic regression model, two or more predictors conferred an odds ratio of 15 (95 percentCI [5.9-37]; P < 0.001) to develop preeclampsia (85 percent specificity, 73 percent sensitivity, c-statistic of 81 ± 4 percent; P < 0.0001). Clinical markers related to insulin resistance and sedentary lifestyles are strong independent predictors of preeclampsia in mothers with 3rd trimester fetal losses or preterm deliveries due to placental insufficiency. Women at risk for preeclampsia in this particular population might benefit from measures focused on overcoming insulin resistance.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pre-Eclampsia
/
Insulin Resistance
/
Sedentary Behavior
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital Federal dos Servidores do Estado/BR
/
Universidade Gama Filho/BR
Similar
MEDLINE
...
LILACS
LIS