Adrenalectomy exacerbates paw edema without interfering with desensitization induced by PAF-acether in rats
Braz. j. med. biol. res
; 21(4): 855-8, 1988. ilus
Article
in En
| LILACS
| ID: lil-60811
Responsible library:
BR26.1
RESUMO
Subcutaneous injection of PAF-acether into rat's paw to a local inflammatory response (edema) followed by desensitization after repeated injections of the substance. The desensitizing effect was not modified by previous adrenalectomy, whereas the inflammatory response observed after the first injection of PAF-acether was exacerbated. This finding suggests that adrenal hormones may act as modulators of PAF-induced inflammatory reactions. Because LY 171883, an LTD4 blocker, inhibited the edema which follows the first injection of PAF-acether, we suggest that leukotrienes may play an important role in the phenomenon
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Index:
LILACS
Main subject:
Platelet Activating Factor
/
Desensitization, Immunologic
/
Leukotriene B4
/
Adrenalectomy
/
Edema
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1988
Type:
Article
/
Congress and conference