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Early diagnosis of relapse in borderline leprosy: two case reports / Diagnóstico precoce de recidiva em hanseníase dimorfa: apresentação de dois casos
Brandão, Maria Luiza Figueiredo Braga; Lima, Cíntia Maria Oliveira; Piñeiro-Maceira, Juan; Miranda, Alice; Oliveira, M. Leide W. de.
  • Brandão, Maria Luiza Figueiredo Braga; UFRJ. University Hospital. Dermatology and Anatomopathology Services. Rio de Janeiro. BR
  • Lima, Cíntia Maria Oliveira; UFRJ. University Hospital. Dermatology and Anatomopathology Services. Rio de Janeiro. BR
  • Piñeiro-Maceira, Juan; UFRJ. University Hospital. Dermatology and Anatomopathology Services. Rio de Janeiro. BR
  • Miranda, Alice; FIOCRUZ. Lab. Hansen 's Disease. Rio de Janeiro. BR
  • Oliveira, M. Leide W. de; UFRJ. University Hospital. Dermatology and Anatomopathology Services. Rio de Janeiro. BR
Rev. Inst. Med. Trop. Säo Paulo ; 53(6): 341-343, Nov.-Dec. 2011. ilus
Article in English | LILACS | ID: lil-608553
ABSTRACT
Two cases of relapse in borderline leprosy were reported. Despite the late-reversal, reaction-like feature, the suspicion of relapse in both was based on persistent and slow-developing skin lesions and an absence of acute neuritis or reaction during one year of follow-up. The authors have considered this possible occurrence in lepromatous borderline-treated patients after their immune cellular restoration and defend that not all Type 1 reactions would be an inflammatory answer to persistent Mycobacterium leprae, but that they could be. Therefore, a relapse diagnosis could be applied and it is more advisable, as one year of Multi-Drug Therapy (MDT) is less dangerous and more efficient for these cases than one year of corticosteroids.
RESUMO
São apresentados dois casos de recidiva de hanseníase borderline. Apesar das características de reação reversa tardia, a suspeita de recidiva foi baseada no desenvolvimento insidioso e persistente de lesões cutâneas sem reação e neurite agudas, durante um ano de seguimento. Os autores consideram a possibilidade de recidiva em pacientes borderline virchowinano tratados, pela restauração da imunidade celular e postulam que embora nem toda reação tipo 1 seja devida a presença de M. leprae persistentes, isso também pode ocorrer. Assim, o diagnóstico de recidiva foi considerado ressaltando-se que um ano de poliquimioterapia oferece menos danos e pode ser mais eficiente nesses casos, que um ano de corticosteróides.
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Full text: Available Index: LILACS (Americas) Main subject: Skin / Leprosy, Borderline / Skin Diseases, Bacterial Type of study: Diagnostic study / Screening study Limits: Adult / Aged / Humans / Male Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: FIOCRUZ/BR / UFRJ/BR

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Full text: Available Index: LILACS (Americas) Main subject: Skin / Leprosy, Borderline / Skin Diseases, Bacterial Type of study: Diagnostic study / Screening study Limits: Adult / Aged / Humans / Male Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: FIOCRUZ/BR / UFRJ/BR