Expresión de marcadores de proliferación celular e invasión tisular en cáncer papilar del tiroides y su asociación con metástasis ganglionares / Expression of proliferation and invasion markers in papilary thyroid carcinoma with and without lymph node involvement
Rev. chil. endocrinol. diabetes
;
2(4): 204-209, oct. 2009. ilus, graf
Article
in Spanish
| LILACS
| ID: lil-610269
ABSTRACT
Background:
Several molecules that may have a role in tumor proliferation, differentiation and invasion, have been detected in thyroid carcinoma. Some of these molecules are NIS, c-MET, TIMP1 an ephrinB2.Aim:
To detect the presence of these molecules in tissue samples of thyroid carcinoma and relate their expression to the biological behavior of the tumor. Material andMethods:
Tissue samples were prospectively obtained from 35 patients operated for a papillary thyroid carcinoma. Twelve patients had regional lymph node involvement. NIS, c-MET, TIMP1 and EphrinB2 were detected by real time polymerase chain reaction(RT-PCR) and immunohistochemistry.Results:
The expression of markers by RT-PCR was non significantly higher among tumors with lymph node involvement. Immunohistochemistryshowed a significantly lower nuclear expression and a higher cytoplasmatic expression of EphrinB2 in tumors with lymph node involvement.Conclusions:
Immunohistochemical expression of EphrinB2 could be useful for the initial staging of papillary thyroid carcinoma.
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Index:
LILACS (Americas)
Main subject:
Thyroid Neoplasms
/
Adenocarcinoma, Papillary
Limits:
Humans
Language:
Spanish
Journal:
Rev. chil. endocrinol. diabetes
Journal subject:
Endocrinology
Year:
2009
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Clínico Universidad de Chile/CL
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