Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study
Braz. j. infect. dis
;
15(6): 533-539, Nov.-Dec. 2011. tab
Article
in English
| LILACS
| ID: lil-610523
ABSTRACT
OBJECTIVE:
To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality.METHODS:
Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis.RESULTS:
Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95 percent confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively).CONCLUSION:
The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pregnancy Complications, Infectious
/
Chlamydia Infections
/
Uterine Cervicitis
/
Perinatal Mortality
Type of study:
Diagnostic study
/
Etiology study
/
Practice guideline
/
Risk factors
/
Systematic reviews
Limits:
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2011
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
UFRN/BR
/
Universidade Estadual de Campinas/BR
/
Universidade Federal do Ceará/BR
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