Atualização do tratamento das vasculites associadas a anticorpo anticitoplasma de neutrófilos / Treatment of antineutrophil cytoplasmic antibody-associated vasculitis: update
J. bras. pneumol
;
37(6): 809-816, nov.-dez. 2011. ilus, tab
Article
in Portuguese
| LILACS
| ID: lil-610915
RESUMO
As vasculites antineutrophil cytoplasmic antibody (ANCA, anticorpo anticitoplasma de neutrófilos) associadas (VAAs) são caracterizadas por uma inflamação sistêmica das artérias de pequeno e médio calibre (especialmente no trato respiratório superior e inferior, e nos rins). As VAAs compreendem a granulomatose de Wegener (agora chamada de granulomatose com poliangeíte), poliangeíte microscópica, VAA limitada ao rim e a síndrome de Churg-Strauss. Neste artigo, discutiremos as fases de tratamento dessas vasculites, como fase de indução (com ciclofosfamida ou rituximab) e fase de manutenção (com azatioprina, metotrexato ou rituximab). Além disso, discutiremos como manusear os casos refratários à ciclofosfamida.
ABSTRACT
In its various forms, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by a systemic inflammation of the small and medium-sized arteries (especially in the upper and lower respiratory tracts, as well as in the kidneys). The forms of AAV comprise Wegener's granulomatosis (now called granulomatosis with polyangiitis), microscopic polyangiitis, renal AAV, and Churg-Strauss syndrome. In this paper, we discuss the phases of AAV treatment, including the induction phase (with cyclophosphamide or rituximab) and the maintenance phase (with azathioprine, methotrexate, or rituximab). We also discuss how to handle patients who are refractory to cyclophosphamide.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Granulomatosis with Polyangiitis
/
Microscopic Polyangiitis
/
Immunosuppressive Agents
Type of study:
Risk factors
Limits:
Humans
Language:
Portuguese
Journal:
J. bras. pneumol
Journal subject:
Pulmonary Disease (Specialty)
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
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