Your browser doesn't support javascript.
loading
Asociación de polimorfismos de los genes CRF-BP, SLC6A4 y restricción alimentaria crónica: un estudio preliminar / CRF-BP and SLC6A4 gene polymorphisms among restrained eaters
Sanhueza, Jorge A; Herrera, Christian L; Salazar, Luis A; Silva, Jaime R.
  • Sanhueza, Jorge A; Universidad de Concepción. Facultad de Ciencias Biológicas. Programa de Magíster en Ciencias Mención Fisiología. Concepción. CL
  • Herrera, Christian L; Universidad de La Frontera. Facultad de Medicina. Departamento de Ciencias Preclínicas. Temuco. CL
  • Salazar, Luis A; Universidad de La Frontera. Facultad de Medicina. Departamento de Ciencias Básicas. Centro de Biología Molecular y Farmacogenética. Temuco. CL
  • Silva, Jaime R; Universidad de La Frontera. Núcleo de Desarrollo Científico-Tecnológico en Biorecursos. Temuco. CL
Rev. méd. Chile ; 139(10): 1261-1268, oct. 2011. ilus, tab
Article in Spanish | LILACS | ID: lil-612192
ABSTRACT

Background:

Restrained eaters (RE) are a group of individuals who constantly restrict their eating. However, they usually alternate restriction with periods of overeating.

Aim:

To evaluate the possible association of CRF-BP and SLC6A4 gene polymorphisms with chronic alimentary restriction. Material and

Methods:

The Spanish version of the Revised Restraint Scale was applied to 132 women aged 18 to 25 years. They were divided in a group classified as restrained eaters (RE) and a group of unrestrained eaters. The 5-HTTLPR and CRF-BPs11 polymorphisms of the SLC6A4 and CRF-BP genes were evaluated by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP), respectively.

Results:

There was a significant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and RE condition (p = 0.033). However, this association was not observed for the CRF-BPs11 polymorphism.

Conclusions:

The presence of s/s genotype is associated with the RE condition, being the presence of a s allele, a risk factor for this condition.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Carrier Proteins / Feeding and Eating Disorders / Serotonin Plasma Membrane Transport Proteins / Gene Frequency Type of study: Etiology study / Observational study / Risk factors Limits: Adolescent / Female / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2011 Type: Article / Project document Affiliation country: Chile Institution/Affiliation country: Universidad de Concepción/CL / Universidad de La Frontera/CL

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Carrier Proteins / Feeding and Eating Disorders / Serotonin Plasma Membrane Transport Proteins / Gene Frequency Type of study: Etiology study / Observational study / Risk factors Limits: Adolescent / Female / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2011 Type: Article / Project document Affiliation country: Chile Institution/Affiliation country: Universidad de Concepción/CL / Universidad de La Frontera/CL