Asociación de polimorfismos de los genes CRF-BP, SLC6A4 y restricción alimentaria crónica: un estudio preliminar / CRF-BP and SLC6A4 gene polymorphisms among restrained eaters
Rev. méd. Chile
;
139(10): 1261-1268, oct. 2011. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-612192
ABSTRACT
Background:
Restrained eaters (RE) are a group of individuals who constantly restrict their eating. However, they usually alternate restriction with periods of overeating.Aim:
To evaluate the possible association of CRF-BP and SLC6A4 gene polymorphisms with chronic alimentary restriction. Material andMethods:
The Spanish version of the Revised Restraint Scale was applied to 132 women aged 18 to 25 years. They were divided in a group classified as restrained eaters (RE) and a group of unrestrained eaters. The 5-HTTLPR and CRF-BPs11 polymorphisms of the SLC6A4 and CRF-BP genes were evaluated by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP), respectively.Results:
There was a significant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and RE condition (p = 0.033). However, this association was not observed for the CRF-BPs11 polymorphism.Conclusions:
The presence of s/s genotype is associated with the RE condition, being the presence of a s allele, a risk factor for this condition.
Full text:
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Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Carrier Proteins
/
Feeding and Eating Disorders
/
Serotonin Plasma Membrane Transport Proteins
/
Gene Frequency
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Female
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2011
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Concepción/CL
/
Universidad de La Frontera/CL
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