Successful treatment of pulmonary Nocardia farcinica infection with linezolid: case report and literature review
Braz. j. infect. dis
;
15(5): 486-489, Sept.-Oct. 2011. ilus, tab
Article
in English
| LILACS
| ID: lil-612711
ABSTRACT
Nocardia infection is rare but potentially fatal. Therapy of Nocardia infection remains difficult. Linezolid, a novel oxazolidinone antibiotic, has proven to be effective, but clinical data are limited. Here we describe a case of a 45-year-old man with pulmonary N. farcinica infection following a liver transplantation. The initial therapy was trimethoprim-sulfamethoxazole, which showed no effect. According to susceptibility test, linezolid was administered with clearly improving the patient's condition. The treatment was stopped for anemia as drug related adverse event, and the therapy lasted for as long as 5 months. At the end of treatment clinical cure was confirmed and anemia reversed after discontinuation of linezolid. We also analyzed the clinical data of previously published reports by literature review, focusing on the efficacy and safety of linezolid treatment for Nocardia infection.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Oxazolidinones
/
Acetamides
/
Anti-Infective Agents
/
Nocardia Infections
Type of study:
Diagnostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2011
Type:
Article
/
Project document
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