Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
Mem. Inst. Oswaldo Cruz
;
107(1): 129-134, Feb. 2012. ilus, mapas
Article
in English
| LILACS
| ID: lil-612816
ABSTRACT
Mutations in the Pfcrt gene that change the resulting amino acids and form different haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) field isolates of the malaria parasite, Plasmodium falciparum. This correlation provides opportunities to infer the global evolutionary history of CQ resistance by analysing CQR Pfcrt haplotype data. We collated data on the Pfcrt haplotypes from different global studies and performed evolutionary genetic analysis to present comprehensive and comparative information on the global distribution of five major CQR-Pfcrt haplotypes and evolutionary inter-relationships among 38 different countries. Using the haplotype diversity data, inter-continental genetic differentiation was also ascertained.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Membrane Transport Proteins
/
Plasmodium falciparum
/
Haplotypes
/
Drug Resistance
/
Protozoan Proteins
/
Chloroquine
/
Antimalarials
Type of study:
Risk factors
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2012
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
Jiwaji University/IN
/
National Institute of Malaria Research/IN
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