TWEAK: ¿una alternativa real en el diagnóstico de nefropatía lúpica? / TWEAK: a real alternative in the diagnosis of lupus nephritis?
Rev. Hosp. Clin. Univ. Chile
;
22(2): 163-170, 2011. ilus, graf
Article
in Spanish
| LILACS
| ID: lil-613264
ABSTRACT
Currently, there is not a marker for early diagnosis of Lupus Nephropathy. TWEAK is a weak Tumor Necrosis Factor whose interaction with the receptor Fn14 in kidney tissue exerts various biological activities including events related to cell proliferation, apoptosis, angiogenesis and inflammation. Because these processes seem to be involved in the pathogenesis of Lupus Nephropathy, it has been proposed that TWEAK could be a potential therapeutic target, but also a predictor of its appearance, and then a possible marker for early diagnosis. The purpose of this article is to discuss the current state of the art in research, of this potential diagnostic tool.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Biomarkers, Tumor
/
Tumor Necrosis Factors
/
Lupus Erythematosus, Systemic
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Humans
Language:
Spanish
Journal:
Rev. Hosp. Clin. Univ. Chile
Journal subject:
Medicine
Year:
2011
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Clínico Universidad de Chile/CL
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