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Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models
Sousa, A. M; Ashmawi, H. A; Costa, L. S; Posso, I. P; Slullitel, A.
  • Sousa, A. M; Universidade de São Paulo. Faculdade de Medicina. LIM-08 - Anestesiologia Experimental. São Paulo. BR
  • Ashmawi, H. A; Universidade de São Paulo. Faculdade de Medicina. LIM-08 - Anestesiologia Experimental. São Paulo. BR
  • Costa, L. S; Universidade de São Paulo. Faculdade de Medicina. LIM-08 - Anestesiologia Experimental. São Paulo. BR
  • Posso, I. P; Universidade de São Paulo. Faculdade de Medicina. LIM-08 - Anestesiologia Experimental. São Paulo. BR
  • Slullitel, A; Hospital Santa Paula. Departamento de Anestesiologia. São Paulo. BR
Braz. j. med. biol. res ; 45(2): 147-152, Feb. 2012. ilus, tab
Article in English | LILACS | ID: lil-614567
ABSTRACT
Local anesthetic efficacy of tramadol has been reported following intradermal application. Our aim was to investigate the effect of perineural tramadol as the sole analgesic in two pain models. Male Wistar rats (280-380 g; N = 5/group) were used in these experiments. A neurostimulation-guided sciatic nerve block was performed and 2 percent lidocaine or tramadol (1.25 and 5 mg) was perineurally injected in two different animal pain models. In the flinching behavior test, the number of flinches was evaluated and in the plantar incision model, mechanical and heat thresholds were measured. Motor effects of lidocaine and tramadol were quantified and a motor block score elaborated. Tramadol, 1.25 mg, completely blocked the first and reduced the second phase of the flinching behavior test. In the plantar incision model, tramadol (1.25 mg) increased both paw withdrawal latency in response to radiant heat (8.3 ± 1.1, 12.7 ± 1.8, 8.4 ± 0.8, and 11.1 ± 3.3 s) and mechanical threshold in response to von Frey filaments (459 ± 82.8, 447.5 ± 91.7, 320.1 ± 120, 126.43 ± 92.8 mN) at 5, 15, 30, and 60 min, respectively. Sham block or contralateral sciatic nerve block did not differ from perineural saline injection throughout the study in either model. The effect of tramadol was not antagonized by intraperitoneal naloxone. High dose tramadol (5 mg) blocked motor function as well as 2 percent lidocaine. In conclusion, tramadol blocks nociception and motor function in vivo similar to local anesthetics.
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Full text: Available Index: LILACS (Americas) Main subject: Sciatic Nerve / Tramadol / Pain Measurement / Analgesics, Opioid / Nerve Block Type of study: Prognostic study Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Santa Paula/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Sciatic Nerve / Tramadol / Pain Measurement / Analgesics, Opioid / Nerve Block Type of study: Prognostic study Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Santa Paula/BR / Universidade de São Paulo/BR