Modification of c and n sources for enhanced production of cyclosporin 'a' by Aspergillus Terreus
Braz. j. microbiol
;
42(4): 1374-1383, Oct.-Dec. 2011. ilus, tab
Article
in English
| LILACS
| ID: lil-614598
ABSTRACT
Most of the studies regarding cyclosporin 'A' production through fungi concentrate around Tolypocladium inflatum. This is mainly due to lower reported production of this drug in other fungi. The present study was therefore conducted to explore indigenous isolates of Aspergillus terreus for synthesis of this drug and defining a production medium for obtaining high yield of cyclosporin 'A'. For this purpose carbon and nitrogen sources were optimized for the selected best strain of A. terreus. Overall results depicted that the best cyclosporin 'A' yield from selected Aspergillus terreus (FCBP58) could be obtained by using production medium containing glucose 10 percent as carbon source and peptone 0.5 percent as nitrogen source. This modification in production medium enhanced drug synthesis by selected fungi significantly. The production capabilities when compared with biomass of fungi there was found no relationship between the two confirming that the medium modification increased overall drug synthesis powers of the fungi.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Aspergillus
/
Cyclosporine
/
Biomass
/
Enzyme Activation
/
Metabolism
/
Nitrogen
Language:
English
Journal:
Braz. j. microbiol
Journal subject:
Microbiology
Year:
2011
Type:
Article
Affiliation country:
Pakistan
Institution/Affiliation country:
University of the Punjab/PK
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