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Is the measurement of inferior thyroid artery blood flow velocity by color-flow Doppler ultrasonography useful for differential diagnosis between gestational transient thyrotoxicosis and Graves' disease? A prospective study
Zuhur, Sayid Shafi; Özel, Alper; Velet, Selvinaz; Buğdacı, Mehmet Sait; Çil, Esra; Altuntas, Yüksel.
  • Zuhur, Sayid Shafi; Sisli Etfal Training and Research Hospital. Endocrinology and Metabolism Clinic. Istanbul. TR
  • Özel, Alper; Sisli Etfal Training and Research Hospital. Radiology Clinic. Istanbul. TR
  • Velet, Selvinaz; Sisli Etfal Training and Research Hospital. Endocrinology and Metabolism Clinic. Istanbul. TR
  • Buğdacı, Mehmet Sait; Sisli Etfal Training and Research Hospital. First Internal Medicine Clinic. Istanbul. TR
  • Çil, Esra; Sisli Etfal Training and Research Hospital. Endocrinology and Metabolism Clinic. Istanbul. TR
  • Altuntas, Yüksel; Sisli Etfal Training and Research Hospital. Endocrinology and Metabolism Clinic. Istanbul. TR
Clinics ; 67(2): 125-129, 2012. tab
Article in English | LILACS | ID: lil-614635
ABSTRACT

OBJECTIVE:

To determine the role of peak systolic velocity, end-diastolic velocity and resistance indices of both the right and left inferior thyroid arteries measured by color-flow Doppler ultrasonography for a differential diagnosis between gestational transient thyrotoxicosis and Graves' disease during pregnancy.

METHODS:

The right and left inferior thyroid artery-peak systolic velocity, end-diastolic velocity and resistance indices of 96 patients with thyrotoxicosis (41 with gestational transient thyrotoxicosis, 31 age-matched pregnant patients with Graves' disease and 24 age- and sex-matched non-pregnant patients with Graves' disease) and 25 ageand sex-matched healthy euthyroid subjects were assessed with color-flow Doppler ultrasonography.

RESULTS:

The right and left inferior thyroid artery-peak systolic and end-diastolic velocities in patients with gestational transient thyrotoxicosis were found to be significantly lower than those of pregnant patients with Graves' disease and higher than those of healthy euthyroid subjects. However, the right and left inferior thyroid artery peak systolic and end-diastolic velocities in pregnant patients with Graves' disease were significantly lower than those of non-pregnant patients with Graves' disease. The right and left inferior thyroid artery peak systolic and end-diastolic velocities were positively correlated with TSH-receptor antibody levels. We found an overlap between the inferior thyroid artery-blood flow velocities in a considerable number of patients with gestational transient thyrotoxicosis and pregnant patients with Graves' disease.

CONCLUSIONS:

This study suggests that the measurement of inferior thyroid artery-blood flow velocities with colorflow Doppler ultrasonography does not have sufficient sensitivity and specificity to be recommended as an initial diagnostic test for a differential diagnosis between gestational transient thyrotoxicosis and Graves' disease during pregnancy.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications / Thyroid Gland / Thyrotoxicosis / Graves Disease / Ultrasonography, Doppler, Color Type of study: Diagnostic study / Observational study Limits: Adult / Female / Humans / Pregnancy Language: English Journal: Clinics Journal subject: Medicine Year: 2012 Type: Article Affiliation country: Turkey Institution/Affiliation country: Sisli Etfal Training and Research Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications / Thyroid Gland / Thyrotoxicosis / Graves Disease / Ultrasonography, Doppler, Color Type of study: Diagnostic study / Observational study Limits: Adult / Female / Humans / Pregnancy Language: English Journal: Clinics Journal subject: Medicine Year: 2012 Type: Article Affiliation country: Turkey Institution/Affiliation country: Sisli Etfal Training and Research Hospital/TR