Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases / Expressão espontânea anômala do receptor de interleucina 8: um breve relato de dois casos
Rev. Soc. Bras. Med. Trop
;
45(1): 134-137, Jan.-Feb. 2012. graf, tab
Article
in English
| LILACS
| ID: lil-614927
ABSTRACT
Interleukin 8 (CXCL8) is an autocrine chemokine specific for the chemoattraction and activation of granulocytes, NKT cells and T lymphocytes. Patients with tuberculosis and latent Mycobacterium tuberculosis infection were assessed for the spontaneous expression of CXCR1 (CD128) and CXCR2 on lymphocytes and monocytes. Compared with ex vivo profiles, increased spontaneous CXCR2 expression and normal CXCR1 expression were found on lymphocytes in two out of 59 individuals. Monocytes showed normal ex vivo profiles for both receptors. After stimulation with purified protein derivative, the in vitro levels of CXCL8 were below the median levels of all patients with prior tuberculosis. Spontaneous CXCR2 modulation did not cause notable variation in the in vitro levels of CXCL8.
RESUMO
Interleucina 8 (CXCL8) é quimiocina autócrina específica para atração e ativação de granulócitos, assim como NKT e linfócitos T. Pacientes com infecção por Mycobacterium tuberculosis e latentes foram recrutados para comparar expressão espontânea dos receptores CXCR1 (CD128) e CXCR2 nos mononucleares. Comparado com perfis ex vivo dos linfócitos, observou-se aumento em CXCR2; porém, expressão normal de CXCR1 em dois dos 59 indivíduos. Monócitos mostraram perfis ex vivo normais; após estimulação específica in vitro das citocinas estudadas com extrato bruto total, não se encontrou correspondência na anomalia observada ex vivo. Modulação espontânea de CXCR2 não causou grande variação in vitro nos níveis de CXCL8.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tuberculosis
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2012
Type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR
/
Laboratory of Clinical Infectious Diseases/US
/
Vanderbilt University School of Medicine/US
Similar
MEDLINE
...
LILACS
LIS