Molecular characterization of MHC-DRB cDNA in water buffalo (Bubalus bubalis)
Genet. mol. biol
;
35(1): 95-98, 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-616999
ABSTRACT
In the present study, water buffalo MHC (Bubu)-DRB cDNA was cloned and characterized. The 1022 base long-amplified cDNA product encompassed a single open reading frame of 801 bases that coded for 266 amino acids. The Bubu-DRB sequence showed maximum homology with the BoLA-DRB3*0101 allele of cattle. A total of seven amino acid residues were found to be unique for the Bubu-DRB sequence. The majority of amino acid substitutions was observed in the β1 domain. Residues associated with important functions were mostly conserved. Water buffalo DRB was phylogenetically closer to goat DRB*A.
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Index:
LILACS (Americas)
Main subject:
Buffaloes
/
DNA, Complementary
/
Dichlororibofuranosylbenzimidazole
Limits:
Animals
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2012
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
Institute Regional Research Station/IN
/
National Bureau of Animal Genetic Resources/IN
/
National Research Centre on Pig/IN
/
Project Directorate on Cattle/IN
/
Pt. Deen Dayal Upadhayaya Veterinary and Animal Sciences University/IN
/
Sri Venkateswara Veterinary University/IN
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