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Pulpotomy in human deciduous teeth and bone morphogenetic protein (rhBMP-2) / Pulpotomia em dentes decíduos humanos e proteína morfogenética do osso (rh BMP-2)
Bengtson, Antonio Lucindo; Bengtson, Nadya Galvão; Bengtson, Camilla Regina Galvão; Pinheiro, Sérgio Luiz; Guedes-Pinto, Antonio Carlos.
  • Bengtson, Antonio Lucindo; Metropolitan University of Santos. School of Dentistry. Department of Pediatric Dentistry. Santos. BR
  • Bengtson, Nadya Galvão; Metropolitan University of Santos. School of Dentistry. Department of Pediatric Dentistry. Santos. BR
  • Bengtson, Camilla Regina Galvão; University of São Paulo. School of Dentistry. Department of Restorative Dentistry. São Paulo. BR
  • Pinheiro, Sérgio Luiz; University of São Paulo. School of Dentistry. Department of Restorative Dentistry. São Paulo. BR
  • Guedes-Pinto, Antonio Carlos; University of São Paulo. School of Dentistry. Department of Pediatric Dentistry. São Paulo. BR
Rev. clín. pesq. odontol. (Impr.) ; 4(3): 129-136, set.-dez. 2008. ilus
Article in English | LILACS, BBO | ID: lil-617350
ABSTRACT

OBJECTIVES:

Recent studies of pulpotomy and direct pulp capping using bone morphogeneticprotein (BMP) in the teeth of animals have indicated a role for BMP in the induction and biologicalproduction of dentin. The aim of this study was to observe painful reactions and signs of clinicaland radiographic pathological alterations in human deciduous teeth, as well as to histologicallyexamine pulp tissue after the use of recombinant human BMP-2 in a collagen scaffold. MATERIALAND

METHOD:

Five deciduous teeth for which pulpotomy had been indicated were studied.rhBMP-2 was placed in the pulp chamber of the teeth, and they were then filled using compositeresin. In two teeth that exfoliated, histological examinations were performed.

RESULTS:

Aftertwelve months, we observed 100% clinical and radiographic success, with no detectableabnormalities. On the histological sections, areas of inflammation, pulp necrosis and internalreabsorption, as well as the formation of tissue resembling osteodentin in the radicular portion,were observed.

CONCLUSIONS:

It could be concluded that the absence of symptomatologyand clinical and radiographic alterations suggests that rhBMP-2 is a material with inductive propertiesthat should be further investigated for use as an alternative to pulpotomy treatment.
RESUMO

OBJETIVOS:

A proposta deste estudo foi observar as reações álgicas, sinais de alteraçõespatológicas (clínica e radiográfica) e examinar histologicamente o tecido pulpar de molaresdecíduos humanos, após o uso de BMP-2 recombinante humano em arcabouço de colágeno.MATERIAL E

MÉTODO:

Foram utilizados cinco molares decíduos de crianças entre oito edez anos, com indicação de pulpotomia. Após execução da técnica, na câmara foi acomodadaa rhBMP-2 em colágeno e o dente restaurado com resina composta. Estes pacientes foramacompanhados durante doze meses, dois dentes que esfoliaram foram realizados exameshistológicos (H.E.).

RESULTADOS:

Após este período observou-se sucesso clínico eradiográfico de 100%, pois nenhuma anormalidade foi detectada. Foram observadas noscortes histológicos, áreas de inflamação, necrose pulpar e reabsorção interna, também formaçãode tecido semelhante a osteodentina.

CONCLUSÕES:

Pode-se concluir que as ausências desintomas e de alterações clínicas e radiográficas sugerem que as rhBMP-2 em arcabouço decolágeno são materiais com propriedades indutivas que devem ser melhor pesquisadas paraque se tornem alternativa para as pulpotomias.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Pulpotomy / Tooth, Deciduous / Recombinant Proteins / Transforming Growth Factor beta / Bone Morphogenetic Proteins / Dental Pulp Limits: Child / Humans Language: English Journal: Rev. clín. pesq. odontol. (Impr.) Journal subject: Dentistry Year: 2008 Type: Article Affiliation country: Brazil Institution/Affiliation country: Metropolitan University of Santos/BR / University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pulpotomy / Tooth, Deciduous / Recombinant Proteins / Transforming Growth Factor beta / Bone Morphogenetic Proteins / Dental Pulp Limits: Child / Humans Language: English Journal: Rev. clín. pesq. odontol. (Impr.) Journal subject: Dentistry Year: 2008 Type: Article Affiliation country: Brazil Institution/Affiliation country: Metropolitan University of Santos/BR / University of São Paulo/BR