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Serotonin transporter gene polymorphisms: a case-control study
Abdo, Evandro Neves; Correia-Silva, Jeane de Fátima; Gomes, Carolina Cavaliéri; Pordeus, Isabela Almeida; Gomez, Ricardo Santiago.
Affiliation
  • Abdo, Evandro Neves; s.af
  • Correia-Silva, Jeane de Fátima; s.af
  • Gomes, Carolina Cavaliéri; s.af
  • Pordeus, Isabela Almeida; Federal University of Minas Gerais. Dental School. Department of Pediatric Dentistry. BR
  • Gomez, Ricardo Santiago; s.af
Braz. dent. j ; 23(1): 68-71, 2012. tab
Article in En | LILACS | ID: lil-618008
Responsible library: BR1.1
ABSTRACT
Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter, are involved in alcoholism and tobacco use and are influenced by polymorphism of the promoter region of 5HTT (5-HTTLPR). As alcohol and tobacco consumption have been implicated in the pathogenesis of oral cancer, the purpose of this study was to investigate 5-HTTLPR polymorphism in patients with oral squamous cell carcinoma (OSCC) compared with a control group in a sample of Brazilian patients. One hundred and three patients affected by OSCC and 103 volunteers without OSCC were genotyped for 5-HTTLPR. Both groups were matched for age, sex and tobacco use. The chi-squared test was used for statistical analysis (α=0.05). There was no statistically significant difference in 5-HTTLPR genotypes between case and control group (p= 0.408). In conclusion, the present investigation demonstrated that serotonin transporter polymorphisms are not implicated in the OSSC development.
RESUMO
Consideráveis evidências indicam que mecanismos serotoninérgicos, particularmente o transportador de serotonina, estão envolvidos no alcoolismo e no uso de fumo e são influenciados pelo polimorfismo da região promotora do 5HTT (5-HTTLPR). Como o consumo de álcool e fumo está implicado na patogênese do câncer, o objetivo deste estudo foi investigar o polimorfismo 5-HTTLPR em pacientes com carcinoma bucal de células escamosas (CBCE) comparado com um grupo controle em uma amostra de pacientes brasileiros. Cento e três pacientes afetados por CBCE e 103 voluntários sem história de CBCE foram genotipados para 5-HTTLPR. Ambos os grupos foram pareados pela idade, gênero e uso de fumo. O teste do qui-quadrado foi usado para análise estatística. Não houve diferença estatística entre os genótipos dos grupos caso e controle (p= 0,408). Concluindo, a presente investigação demonstrou que os polimorfismos do transportador de serotonina não estão implicados no desenvolvimento do CBCE.
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Full text: 1 Index: LILACS Main subject: Polymorphism, Genetic / Mouth Neoplasms / Smoking / Alcoholism / Serotonin Plasma Membrane Transport Proteins Type of study: Etiology_studies / Observational_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Braz. dent. j Journal subject: ODONTOLOGIA Year: 2012 Type: Article

Full text: 1 Index: LILACS Main subject: Polymorphism, Genetic / Mouth Neoplasms / Smoking / Alcoholism / Serotonin Plasma Membrane Transport Proteins Type of study: Etiology_studies / Observational_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Braz. dent. j Journal subject: ODONTOLOGIA Year: 2012 Type: Article