Influence of periodontal therapy on C-reactive protein level: a systematic review and meta-analysis
J. appl. oral sci
;
20(1): 1-8, Jan.-Feb. 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-618146
ABSTRACT
The influence of oral infections, especially periodontal disease, on systemic diseases has been extensively discussed in the literature. Because periodontal disease is a persistent infection, it promotes an inflammatory response. C-reactive protein is a marker for inflammatory reactions that is frequently studied, since elevated levels of this protein are related to coronary events. OBJECTIVE:
The aim of this study was to investigate the effect of periodontal therapy on reducing the serum levels of C-reactive protein, by means of a systematic review of the literature and meta-analysis. MATERIAL ANDMETHODS:
A systematic review of the English-language literature was conducted in the PUBMED-MEDLINE database, using the key words "periodontal disease", "C-reactive protein", "periodontal therapy" and "periodontal treatment", in accordance with the terms for Medical Subject Headings (MeSH), to evaluate the effect of periodontal therapy on C-reactive protein levels. A qualitative analysis of studies of randomized clinical trial design was performed using CONSORT, with subsequent meta-analysis.RESULTS:
The literature search initially retrieved 46 potentially relevant studies available in the databases. From these, in accordance with the inclusion criteria, only 11 were selected, of which only 4 fulfilled the criteria of randomized clinical trial design. According to CONSORT, the studies evaluated generally presented good quality with regard to the criteria analyzed. Through meta-analysis, the reduction in mean levels of C-reactive protein (-0.231; p=0.000) after introducing periodontal treatment was estimated. The result was statistically significant, without evidence of heterogeneity between the studies (p=0.311).CONCLUSIONS:
The findings indicated that non-surgical periodontal treatment had a positive effect with regard to reduction of the serum levels of C-reactive protein.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Periodontal Diseases
/
C-Reactive Protein
Type of study:
Controlled clinical trial
/
Etiology study
/
Qualitative research
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Bahia School of Medicine and Public Health/BR
/
Federal University of Bahia Recôncavo/BR
/
Feira de Santana State University/BR
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