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Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom
Rodríguez, J P; Gay, C C; Fusco, L S; Gauna, M C; Acosta, O C; Leiva, L C.
  • Rodríguez, J P; National University of the Northeast. School of Exact and Natural Sciences and Land Surveying. Laboratory of Protein Research. Corrientes. AR
  • Gay, C C; National University of the Northeast. School of Exact and Natural Sciences and Land Surveying. Laboratory of Protein Research. Corrientes. AR
  • Fusco, L S; National University of the Northeast. School of Exact and Natural Sciences and Land Surveying. Laboratory of Protein Research. Corrientes. AR
  • Gauna, M C; National University of the Northeast. School of Exact and Natural Sciences and Land Surveying. Laboratory of Protein Research. Corrientes. AR
  • Acosta, O C; National University of the Northeast. School of Veterinary Sciences. Laboratory of Pharmacology. Corrientes. AR
  • Leiva, L C; National University of the Northeast. School of Exact and Natural Sciences and Land Surveying. Laboratory of Protein Research. Corrientes. AR
J. venom. anim. toxins incl. trop. dis ; 18(1): 116-123, 2012. ilus, graf
Article in English | LILACS | ID: lil-618198
ABSTRACT
Cross-neutralization of Crotalus durissus terrificus venom coagulant activity was tested using bivalent horse antivenom against Bothrops alternatus and Bothrops diporus venoms. Our in vitro and in vivo experiments showed that bothropic antivenom neutralizes the thrombin-like activity of crotalic snake venom and this cross-reaction was demonstrated by immunoassays either with whole venom or a purified thrombin-like enzyme. These results suggest common antigenic properties and, consequently, similar molecular structure among venom thrombin-like enzymes. Besides, they provide information that could be further used in the development of new antivenom formulations.
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Full text: Available Index: LILACS (Americas) Main subject: Antivenins / Crotalid Venoms Limits: Animals Country/Region as subject: South America / Argentina Language: English Journal: J. venom. anim. toxins incl. trop. dis Journal subject: Toxicology Year: 2012 Type: Article / Project document Affiliation country: Argentina Institution/Affiliation country: National University of the Northeast/AR

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Full text: Available Index: LILACS (Americas) Main subject: Antivenins / Crotalid Venoms Limits: Animals Country/Region as subject: South America / Argentina Language: English Journal: J. venom. anim. toxins incl. trop. dis Journal subject: Toxicology Year: 2012 Type: Article / Project document Affiliation country: Argentina Institution/Affiliation country: National University of the Northeast/AR