Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom
J. venom. anim. toxins incl. trop. dis
;
18(1): 116-123, 2012. ilus, graf
Article
in English
| LILACS
| ID: lil-618198
ABSTRACT
Cross-neutralization of Crotalus durissus terrificus venom coagulant activity was tested using bivalent horse antivenom against Bothrops alternatus and Bothrops diporus venoms. Our in vitro and in vivo experiments showed that bothropic antivenom neutralizes the thrombin-like activity of crotalic snake venom and this cross-reaction was demonstrated by immunoassays either with whole venom or a purified thrombin-like enzyme. These results suggest common antigenic properties and, consequently, similar molecular structure among venom thrombin-like enzymes. Besides, they provide information that could be further used in the development of new antivenom formulations.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Antivenins
/
Crotalid Venoms
Limits:
Animals
Country/Region as subject:
South America
/
Argentina
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Journal subject:
Toxicology
Year:
2012
Type:
Article
/
Project document
Affiliation country:
Argentina
Institution/Affiliation country:
National University of the Northeast/AR
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