Histocompatibility antigens and insulin-dependent diabetes: a study of 20 brazilian families
Braz. j. med. biol. res
;
14(6): 379-81, Dec. 1981. tab
Article
in English
| LILACS
| ID: lil-61882
ABSTRACT
The relationship between histocompatibility antigens (HLA) and insulin-dependent diabetes was examined. The relative frequency of HLA and the relative risk were determined for 20 families containing 82 individuals, 23 of whom hda insulin-dependent diabetes. The control group contained 102 individuals. 2 The B8, B13, and B15 antigens had the highest relative frequency in the group of diabetic patients, whereas B5, B7 and B12 were lowest. A high relative frequency of histocompatibility antigens was found not only in the diabetic patients, but also in their parents and siblings. There was a predominance of A2B8, A2B15, and A9B15 haplotypes in the diabetic population. The diabetic siblings hda identical haplotypes. 3. These data support previous reports suggesting gwenetic linkage between susceptibility to diabetes and the histocompatibility antigen systen
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Index:
LILACS (Americas)
Main subject:
Diabetes Mellitus, Type 1
/
Gene Frequency
/
HLA Antigens
Type of study:
Etiology study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1981
Type:
Article
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