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Óleo essencial de Thymus vulgaris sobre o crescimentode Streptococcus mutans / Effect of the Thymus vulgaris essential oil on the growth of Streptococcus mutans
Gonçalves, G. M. S; Bottaro, M; Nilson, A. C.
  • Gonçalves, G. M. S; Pontifical Catholic University of Campinas. Faculty of Pharmaceutical Sciences. Campinas. BR
  • Bottaro, M; Pontifical Catholic University of Campinas. Faculty of Pharmaceutical Sciences. Campinas. BR
  • Nilson, A. C; Pontifical Catholic University of Campinas. Faculty of Pharmaceutical Sciences. Campinas. BR
Article in English | LILACS | ID: lil-621572
ABSTRACT
The traditional Mediterranean herb thyme (Thymus vulgaris) is a source of an essential oil that has been shown to possess antimicrobial activity against many microorganisms. A considerable part of the general population has dental caries and Streptococcus mutans is one of the microorganisms responsible. The aim of this study was to assess the effect of the essential oil extracted from thyme on the growth of S. mutans, the main bacterium involved in the etiology of dental caries, as well as to incorporate this oil into a toothpaste formulation for preliminary assessment. The broth dilution technique was used in threefold tests for antibacterial activity. The concentrations tested were 1%, 5% and 10% essential oil diluted in ethanol or mineral oil. The controls were triclosan at 0.25% and 0.5%, chlorhexidine digluconate at 0.06% and 0.12%, and ethanol. The 1% solution of thyme essential oil in ethanol proved to be the most efficient against Streptococcus mutans and may be considered viable as an ingredient of toothpaste, both with regard to cost and to the sensory profile of the product. Also, analyses of the characteristics of the formulation indicated that the product is stable.
RESUMO
Thymus vulgaris (tomilho) é uma fonte de óleo essencial que tem demonstrado atividade antimicrobiana. Uma parcela considerável da população tem apresentado problemas dentários, tais como a cárie, na qual o Streptococcus mutans é um microrganismo de fundamental importância. O objetivo deste trabalho foi avaliar o efeito do óleo essencial de tomilho sobre o crescimento do Streptococcus mutans, a principal bactéria relacionada com a etiologia da cárie dentária, bem como veicular este óleo essencial em uma formulação de creme dental para estudo preliminar. O método empregado foi diluição em caldo. As concentrações utilizadas de óleo essencial foram 1%, 5% e 10% de óleo essencial diluído em etanol ou óleo mineral. Os controles foram triclosan a 0,25% e 0,5%, bem como digluconato de clorexidina a 0,06% e 0,12%. A amostra contendo 1% de óleo essencial de tomilho diluída em etanol foi a mais eficaz, sendo efetiva contra Streptococcus mutans e, portanto considerada viável em relação ao custo e ao sensorial conferido ao produto, sendo que a formulação avaliada foi considerada estável.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Streptococcus mutans / Oils, Volatile / Microbial Sensitivity Tests / Thymus serpyllum / Dental Caries / Anti-Bacterial Agents Language: English Journal: Rev. ciênc. farm. básica apl Journal subject: Pharmacology Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Pontifical Catholic University of Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Streptococcus mutans / Oils, Volatile / Microbial Sensitivity Tests / Thymus serpyllum / Dental Caries / Anti-Bacterial Agents Language: English Journal: Rev. ciênc. farm. básica apl Journal subject: Pharmacology Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Pontifical Catholic University of Campinas/BR