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Dental pulp stem cells express proteins involved in the local invasiveness of odontogenic myxoma
Miyagi, Sueli Patricia Harumi; Maranduba, Carlos Magno da Costa; Silva, Fernando de Sá; Marques, Márcia Martins.
  • Miyagi, Sueli Patricia Harumi; Universidade de São Paulo. São Paulo. BR
  • Maranduba, Carlos Magno da Costa; Universidade Federal de Juiz de Fora. Department of Biology. BR
  • Silva, Fernando de Sá; Universidade de São Paulo. São Paulo. BR
  • Marques, Márcia Martins; Universidade de São Paulo. São Paulo. BR
Braz. oral res ; 26(2): 139-144, Mar.-Apr. 2012. ilus, tab
Article in English | LILACS | ID: lil-622910
ABSTRACT
Little is known about the histogenesis of the odontogenic myxoma (OM). Dental pulp stem cells could be candidate precursors of OM because both OM and the dental pulp share the same embryological origin the dental papilla. For the purpose of comparing OM and stem cells, this study analyzed the expression of two proteins related to OM invasiveness (MMP-2 and hyaluronic acid) in human immature dental pulp stem cells (hIDPSCs). Three lineages of hIDPSCs from deciduous and permanent teeth were used in this study. Immunofluorescence revealed positive reactions for MMP-2 and hyaluronic acid (HA) in all hIDPSCs. MMP-2 appeared as dots throughout the cytoplasm, whereas HA appeared either as diffuse and irregular dots or as short fibrils throughout the cytoplasm and outside the cell bodies. The gene expression profile of each cell lineage was evaluated using RT-PCR analysis, and HA was expressed more intensively than MMP-2. HA expression was similar among the three hIDPSCs lineages, whereas MMP-2 expression was higher in DL-1 than in the other cell lines. The expression of proteins related to OM invasiveness in hIDPSCs could indicate that OM originates from dental pulp stem cells.
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Full text: Available Index: LILACS (Americas) Main subject: Stem Cells / Odontogenic Tumors / Dental Pulp / Hyaluronic Acid / Myxoma Limits: Adolescent / Child / Child, preschool / Humans Language: English Journal: Braz. oral res Journal subject: Dentistry Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Juiz de Fora/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Stem Cells / Odontogenic Tumors / Dental Pulp / Hyaluronic Acid / Myxoma Limits: Adolescent / Child / Child, preschool / Humans Language: English Journal: Braz. oral res Journal subject: Dentistry Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Juiz de Fora/BR / Universidade de São Paulo/BR