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Low prevalence of gingival overgrowth associated to new imunossupressive protocols with cyclosporin
Wentz, Luiz Augusto; Oliveira, Sara Cioccari; Moreira, Carlos Heitor Cunha; Rösing, Cassiano Kuchenbecker.
  • Wentz, Luiz Augusto; Federal University of Santa Maria. School of Dentistry. Santa Maria. BR
  • Oliveira, Sara Cioccari; Federal University of Santa Maria. School of Dentistry. Santa Maria. BR
  • Moreira, Carlos Heitor Cunha; Federal University of Santa Maria. School of Dentistry. Department of Stomatology. Santa Maria. BR
  • Rösing, Cassiano Kuchenbecker; Universidade Federal do Rio Grande do Sul. School of Dentistry. Department of Periodontics. Porto Alegre. BR
Braz. oral res ; 26(1): 64-70, Jan.-Feb. 2012. graf, tab
Article in English | LILACS | ID: lil-622929
ABSTRACT
Gingival overgrowth (GO) is a frequent finding in patients treated with cyclosporine (CsA). This study investigated the prevalence and severity of GO in patients who received kidney transplant and CsA therapy, as well as associations with pharmacological and clinical factors. This cross-sectional study included 63 kidney transplant recipients who were treated with CsA in a university hospital. Demographic, pharmacological, and periodontal data were collected. The primary variable was GO. Independent sample t- and chi-square tests were used to compare means in groups with versusl without GO. The response rate was 86.3%. Overall, 40% of patients had some degree of GO. Eleven individuals presented GO scores > 10%, and 5 individuals reached 30%. The mean GO percentage was low (6.79 ± 15.83). Patients that were concurrently under nifedipine treatment showed a non-significant trend toward a greater prevalence of GO. Mean CsA dosage and serum levels were 3.20 ± 0.94 mg/kg/d and 156.12 ± 162.75 ng/mL, respectively. There were no statistically significant differences between patients with versusl without GO nor between the groups receiving nifedipine, no drug, or verapamil. The GO prevalence and severity rates were lower than those reported in previous studies and seemed to be independent of drug interactions.
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Full text: Available Index: LILACS (Americas) Main subject: Cyclosporine / Gingival Overgrowth / Immunosuppressive Agents Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. oral res Journal subject: Dentistry Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Santa Maria/BR / Universidade Federal do Rio Grande do Sul/BR

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Full text: Available Index: LILACS (Americas) Main subject: Cyclosporine / Gingival Overgrowth / Immunosuppressive Agents Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. oral res Journal subject: Dentistry Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Santa Maria/BR / Universidade Federal do Rio Grande do Sul/BR