The immune-dependence of chemotherapy in experimental schistosomiasis
Mem. Inst. Oswaldo Cruz
;
84(supl.1): 31-37, 1989.
Article
in English
| LILACS
| ID: lil-623563
ABSTRACT
Experimental evidence indicates that immune effector mechanisms can enhance the activity of schistosomicidal drugs. Praziquantel, oxamniquine, hycanthone and antimony were less effective against Schistosoma mansoni infections in mice immunosuppressed by T cell-deprivation, than against comparable infection in normal mice. The schistosomicidal activities of praziquantel, oxamniquine and antimony have been experimentally enhanced by the synergistic action of immune sera. In passive serum transfer experiments a s. mansoni antigen of Mr 27 kD with non-specific esterase activity was identified as a potentially sensitive target for the antibodies that interact with praziquantel. Indirect immunofluorescence indicated that this antigen was exposed on the worm surface as a result of praziquantel treatment.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Schistosoma mansoni
/
Schistosomicides
/
Schistosomiasis mansoni
/
Antibodies, Helminth
/
Immune Sera
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1989
Type:
Article
/
Congress and conference
Affiliation country:
United kingdom
Institution/Affiliation country:
London School of Hygiene and Tropical Medicine/GB
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