Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms
Mem. Inst. Oswaldo Cruz
;
82(supl.4): 105-109, 1987. graf, tab
Article
in English
| LILACS
| ID: lil-623672
ABSTRACT
Anti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab')2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.
Full text:
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Index:
LILACS (Americas)
Main subject:
Arginase
/
Schistosomiasis
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1987
Type:
Article
/
Congress and conference
/
Project document
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Centro de Pesquisas René Rachou/BR
/
Texas A & M Univ/US
/
Univ Fed Juiz de Fora/BR
/
Vanderbilt Univ/US
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