Prospects for a nonliving vaccine against Schistosomiasis based on cell-mediated immune resistance mechanisms
Mem. Inst. Oswaldo Cruz
;
82(supl.4): 121-123, 1987.
Article
in English
| LILACS
| ID: lil-623675
ABSTRACT
We have designed a vaccine model based on induction of cell-mediated immunity and shown that it protects mice against Schistosoma mansoni infection. Mice are immunized by intradermal injection with schistosome antigens plus BCG. Resistance is dependent on the route of antigen presentation and the adjuvant chosen. The pattern of resistance correlates with sensitization of T lymphocytes for production of gamma interferon, a macrophage activating lymphokine that stimulates the cellular effector mechanism of protection. Purified schistosome paramyosin, a muscle cell component present in soluble parasite antigenic preparations, is immunogenic for T lymphocytes and induces resistance when given intradermally with BCG. It is likely that this protein, and possibly other soluble molecules that are released by the parasites of a challenge infection, induce a cellular inflammatory response resulting in larval trapping and/or killing by activated macrophages. These results verify the feasibility of a vaccine against schistosomiasis based on induction of cell-mediated immune resistance mechanisms.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Adjuvants, Immunologic
/
Antigens, Helminth
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1987
Type:
Article
/
Congress and conference
/
Project document
Affiliation country:
United States
Institution/Affiliation country:
NIH/US
/
The George Washington University/US
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