Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection
Mem. Inst. Oswaldo Cruz
;
82(supl.4): 237-241, 1987. ilus
Article
in English
| LILACS
| ID: lil-623700
ABSTRACT
We have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1:256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Passive Cutaneous Anaphylaxis
/
Antibodies, Helminth
/
Toxocariasis
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1987
Type:
Article
/
Congress and conference
/
Project document
Affiliation country:
Japan
Institution/Affiliation country:
Chiba University/JP
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