Schistosoma mansoni: structural damage after treatment with oxamniquine
Mem. Inst. Oswaldo Cruz
;
82(supl.4): 347-352, 1987. ilus
Article
in English
| LILACS
| ID: lil-623722
ABSTRACT
The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially and simultaneously described in form of swelling, surface bulble and disruption with erosions. Ulceration in the tubercules with loss of spines is often more extensive and severe in male worms and concentration of host's mononuclear cells is observed. The possible role of host's immune response is discussed.
Full text:
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Index:
LILACS (Americas)
Main subject:
Schistosoma mansoni
/
Nitroquinolines
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1987
Type:
Article
/
Congress and conference
Affiliation country:
Brazil
Institution/Affiliation country:
FIOCRUZ/BR
/
UFPE/BR
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