The nature of autoantigens
Mem. Inst. Oswaldo Cruz
;
82(supl.2): 105-109, 1987. tab, graf
Article
in English
| LILACS
| ID: lil-623770
ABSTRACT
1. Autoimmunity in deisease is driven by autoantigen; 2. Cell surface molecules may stimulate autoreactive T-helpers if call II MHC is expressed; special factors may predispose to the ease of class II induction; 3. Soluble autoantigens may be focussed by primed B-cells and processed for presentation to T-cell; 4. autoantigenicity may be influenced by metabolic events (a) Poorly iodinated thyroglobulin does not induce thyroiditis; (b) IgG rheumatoid arthritis has galactose deficient Fc oligosaccharides. Glycosylation defects may prove to have wide implications.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Autoimmune Diseases
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1987
Type:
Article
/
Congress and conference
Affiliation country:
United kingdom
Institution/Affiliation country:
Middlesex Hospital Medical School/GB
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