The rational search for natural neolignans
Mem. Inst. Oswaldo Cruz
;
86(supl.2): 25-29, 1991. ilus
Article
in English
| LILACS
| ID: lil-623935
ABSTRACT
A rational method of search for natural neolignans of desired structures is outlined. This involves consultation of a collection of chemical profiles of plant families. The profiles are assembled considering the biosynthetic class (in the present case lignoids), subclass (neolignans), structural types (neolignan skeleta) and relative frequency of substitutional derivatives belonging to each type (known compounds). The method is of course applicable to ani class of natural products. Its use in the case of neolignans is here selected as an exemple in view of the recently discovered antagonism towards PAF of kadsurenone, a representative of this subclass of phytochemicals. Application of the chemical profiles to phylogenetic studies is illustrated.
Full text:
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Index:
LILACS (Americas)
Main subject:
Plants
/
Recombinant Proteins
/
Lignans
/
Phytochemicals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1991
Type:
Article
/
Congress and conference
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
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