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Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
Rao, V. S. N; Almeida, F. R. C; Moraes, A. P; Silva, J. V; Nascimento, S. C; Moraes, M. O.
  • Rao, V. S. N; UFC. Departamento de Fisiologia e Farmacologia. Labortório de Pesquisas Antineoplásticas. Fortaleza. BR
  • Almeida, F. R. C; UFC. Departamento de Fisiologia e Farmacologia. Labortório de Pesquisas Antineoplásticas. Fortaleza. BR
  • Moraes, A. P; UFC. Departamento de Fisiologia e Farmacologia. Labortório de Pesquisas Antineoplásticas. Fortaleza. BR
  • Silva, J. V; UFC. Departamento de Fisiologia e Farmacologia. Labortório de Pesquisas Antineoplásticas. Fortaleza. BR
  • Nascimento, S. C; Universidade Federal de Pernambuco. Departamento de Antibióticos. Recife. BR
  • Moraes, M. O; UFC. Departamento de Fisiologia e Farmacologia. Labortório de Pesquisas Antineoplásticas. Fortaleza. BR
Mem. Inst. Oswaldo Cruz ; 86(supl.2): 43-45, 1991. tab
Article in English | LILACS | ID: lil-623938
ABSTRACT
Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).
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Full text: Available Index: LILACS (Americas) Main subject: Triterpenes / Antineoplastic Agents, Phytogenic Limits: Animals / Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 1991 Type: Article / Congress and conference Affiliation country: Brazil Institution/Affiliation country: UFC/BR / Universidade Federal de Pernambuco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Triterpenes / Antineoplastic Agents, Phytogenic Limits: Animals / Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 1991 Type: Article / Congress and conference Affiliation country: Brazil Institution/Affiliation country: UFC/BR / Universidade Federal de Pernambuco/BR