Genotoxic effect of alkaloids
Mem. Inst. Oswaldo Cruz
;
86(supl.2): 71-74, 1991. tab
Article
in English
| LILACS
| ID: lil-623944
ABSTRACT
Because of the increase use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotixicity in the presence of a metabolic activation mixture. Voacristine isolated fromthe leaves of Ervatamia coronaria shows in vivo cytostatic and mutagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.
Full text:
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Index:
LILACS (Americas)
Main subject:
Recombination, Genetic
/
Saccharomyces cerevisiae
/
Alkaloids
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1991
Type:
Article
/
Congress and conference
Affiliation country:
Brazil
Institution/Affiliation country:
UFRGS/BR
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