Evaluation of acute administration of natural products with potential diuretic effects, in humans
Mem. Inst. Oswaldo Cruz
;
86(supl.2): 237-240, 1991. ilus, tab
Article
in English
| LILACS
| ID: lil-623978
ABSTRACT
In order to evaluate the potential diuretic effect of two natural products, Elephantopus scaber and Alpinia speciosa, a trial administration was carried out in ten healthy volunteers and the effects compared to the those of a placebo. The substances were given on different days, with a seven day interval between doses. The amount of substance administered to the subjects was five times the usual dose i.e. 7.5 g/100 ml and 0.8 g/100 ml respectively. The following parameters parameteres were measured urinary and plasma sodium, potassium, uric acid, calcium, phosphate, urea, creatinine. The subjects were also examined clinically and total urinary volume was assessed. The only significant finding (p < 0.05) was a slight diuresis with Alpinia speciosa, which also lowered the diastolic (p < 0.05) and systolic (p < 0.01) blood pressures. No effect on electrolytes or renal function parameters was observed, and this probably excludes any renal tubular or glomerular effect from these substances. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Urine
/
Blood Pressure
/
Diuretics
/
Electrolytes
/
Natriuresis
Type of study:
Controlled clinical trial
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1991
Type:
Article
/
Congress and conference
Affiliation country:
Brazil
Institution/Affiliation country:
Escola Paulista de Medicina/BR
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