The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates
Mem. Inst. Oswaldo Cruz
;
107(3): 433-436, May 2012. tab
Article
in English
| LILACS
| ID: lil-624029
ABSTRACT
The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C. glabrata has been less studied than other species. In this paper, we compared the activity of three major classes of antifungal agents (azoles, echinocandins and polyenes) against fluconazole-susceptible (FS) and fluconazole-resistant (FR) C. glabrata strains. Cross-resistance between fluconazole and voriconazole was remarkable. Among the antifungal agents, the echinocandins were the most effective against FS and FR C. glabrata and micafungin showed the lowest minimal inhibitory concentrations.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pyrimidines
/
Triazoles
/
Fluconazole
/
Amphotericin B
/
Candida glabrata
/
Echinocandins
/
Antifungal Agents
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Complexo Hospitalar Santa Casa de Misericórdia/BR
/
Universidade Federal de Santa Maria/BR
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