Ethnobotanical, pharmacognostical, pharmacological and phytochemical studies on Smilax domingensis in Guatemala
Rev. bras. farmacogn
;
22(2): 239-248, Mar.-Apr. 2012. ilus, graf
Article
in English
| LILACS
| ID: lil-624661
ABSTRACT
Smilax domingensis Willd., Smilacaceae, known as zarzaparrilla, is a climbing shrub from Tropical America. The rhizome is popularly used in medicine as anti-inflammatory, antiseptic, and tonic. Since 1983 studies are being conducted in Guatemala for validation of the ethnobotanical uses, particularly in vitro demonstration of antimicrobial activity, using wild material, with high variability and some taxonomic problems. This article reports the taxonomic determination, cultivation of drug material, evaluation of use by in vitro and in vivo pharmacological assays, and phytochemical characterization. Extracts from cultivated material was evaluated by antimicrobial, anti-inflammatory, analgesic and immunomodulatory models, confirming the antimicrobial and immunomodulatory activities. Phytochemistry was done in the crude drug and extracts. Quality control parameters are described (micrographic drawings and phytochemical characteristics). Evidence is presented that cultivated rhizome has antimicrobial and immunomodulatory activities, validating the popular use and helping the industrial development of phytopharmaceutical products.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Prognostic study
Country/Region as subject:
Central America
/
Guatemala
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2012
Type:
Article
Affiliation country:
Argentina
/
Guatemala
Institution/Affiliation country:
Universidad Nacional de Rosario/AR
/
Universidad de San Carlos/GT
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