Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats
Rev. bras. farmacogn
;
22(3): 663-668, May-June 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-624695
ABSTRACT
This work presents the observed changes in Wistar rats under long treatment (thirteen weeks) with different oral doses of the ethanolic extract (EE) from Jatropha gossypiifolia L., Euphorbiaceae. The most significant toxic signs indicated a reduction of the activity in the central nervous system and digestive disturbances. The histopathological analysis shows hepatotoxity and pulmonary damages. The lethality was 46.6% among males under the higher experimental dose (405 mg/kg) and 13.3% both in females under the higher dose and among the animals treated with 135 mg/kg of the product. These data show the significant oral chronic toxicity of EE of J. gossypiifolia in rats.
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Index:
LILACS (Americas)
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal da Paraíba/BR
/
Universidade Federal de Campina Grande/BR
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