Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida
Rev. bras. farmacogn
;
22(3): 598-603, May-June 2012. ilus
Article
in English
| LILACS
| ID: lil-624704
ABSTRACT
The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4'-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, ethyl acetate fraction, and 1. In the hot plate test, mice pretreated with 1 showed significantly increased reaction times (60-89%). Oral administration of 1 significantly inhibited first and second phases of the formalin-induced pain (50 and 26.5%, respectively), whereas indomethacin inhibited only the second phase of the test (41.2%). Ethanol extract and its fraction showed effects on inflammatory pain, while neurogenic and inflammatory pain suppression by 1 is a strong indication of the presence of both central and peripheral effects and suggests its analgesic and anti-inflammatory potential.
Full text:
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Index:
LILACS (Americas)
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2012
Type:
Article
Affiliation country:
Brazil
/
Italy
Institution/Affiliation country:
Universidade Federal de Alagoas/BR
/
Universidade Federal de Sergipe/BR
/
Universidade Federal do Rio de Janeiro/BR
/
Università Degli Studi di Salerno/IT
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