Predisposición genética para el cáncer de mama: genes BRCA1 y BRCA2

Narod, Steven A; Rodríguez, Adriana A

Predisposición genética para el cáncer de mama: genes BRCA1 y BRCA2 / Genetic predisposition for breast cancer: BRCA1 and BRCA2 genes

Narod, Steven A; Rodríguez, Adriana A.

Narod, Steven A; University of Toronto. Women's College Research Institute. Toronto. CA
Rodríguez, Adriana A; Baylor College of Medicine. Department of Molecular and Cellular Biology. Houston. US

Salud pública Méx ; 53(5): 420-429, sept.-oct. 2011. tab

Article in Spanish | LILACS | ID: lil-625728

RESUMEN
ABSTRACT

RESUMEN

El descubrimiento de los genes BRCA1 y BRCA2 ha llevado a la introducción de pruebas genéticas cada vez más sofisticadas para medir el riesgo de cáncer de mama de origen hereditario, entre otras cosas. En el presente artículo exploramos los criterios a seguir para realizar pruebas para estos genes, así como las implicaciones en el tratamiento para los pacientes en caso de identificarlos.

ABSTRACT

The discovery of genes BRCA1 and BRCA2 has led to the introduction of genetic tests more complex every time for the evaluation ofthehereditarycancerrisk,amongothers.In the present paper we explore the criteria to decide when to run the testing for the genes, as well as the implications for the treatment of patients who are identified with them.

Subject(s)

Female; Humans; Breast Neoplasms/genetics; Genes, BRCA1; Genetic Testing; Neoplastic Syndromes, Hereditary/genetics; Breast Neoplasms/classification; Breast Neoplasms/epidemiology; Breast Neoplasms/pathology; Breast Neoplasms/prevention & control; Comorbidity; Estrogen Receptor Modulators/therapeutic use; Estrogens/adverse effects; Ethnicity/genetics; Family Health; Forecasting; Founder Effect; Gene Frequency; Genetic Predisposition to Disease/genetics; Mastectomy; Mexico/epidemiology; Neoplasms, Hormone-Dependent/epidemiology; Neoplasms, Hormone-Dependent/genetics; Neoplasms, Hormone-Dependent/pathology; Neoplasms, Multiple Primary/epidemiology; Neoplasms, Multiple Primary/genetics; Neoplastic Syndromes, Hereditary/epidemiology; Ovarian Neoplasms/epidemiology; Ovarian Neoplasms/genetics; Ovarian Neoplasms/prevention & control; Reproductive History; Risk

BRCA1; BRCA1; BRCA2; BRCA2; Breast neoplasms; Genetics; Genética; Neoplasias de la mama; Oncogenes; Oncogenes

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Full text: Available Index: LILACS (Americas) Main subject: Neoplastic Syndromes, Hereditary / Breast Neoplasms / Genetic Testing / Genes, BRCA1 Type of study: Etiology study / Prognostic study / Risk factors Limits: Female / Humans Country/Region as subject: Mexico Language: Spanish Journal: Salud pública Méx Journal subject: Public Health Year: 2011 Type: Article Affiliation country: Canada / United States Institution/Affiliation country: Baylor College of Medicine/US / University of Toronto/CA

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