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Different effects of scopolamine on learning, memory, and nitric oxide metabolite levels in hippocampal tissues of ovariectomized and Sham-operated rats / Diferentes efeitos da escopolamina no aprendizado, na memória e nos níveis dos metabólitos do óxido nítrico no tecido hipocampal de ratas ooforectomizadas e controles operadas sem ooforectomia
Azizi-Malekabadi, Hamid; Hosseini, Mahmoud; Soukhtanloo, Mohammad; Sadeghian, Reihaneh; Fereidoni, Masoud; Khodabandehloo, Fatimeh.
  • Azizi-Malekabadi, Hamid; Islamic Azad University, Khorasgan Branch. Faculty of Basic Sciences. Isfahan. IR
  • Hosseini, Mahmoud; Mashhad University of Medical Sciences. Neuroscience Research Center. Department of Physiology. Mashhad. IR
  • Soukhtanloo, Mohammad; Mashhad University of Medical Sciences. School of Medicine. Department of Biochemistry. Mashhad. IR
  • Sadeghian, Reihaneh; Ferdowsi University of Mashhad. Faculty of Sciences. Deptartment of Biology. Mashhad. IR
  • Fereidoni, Masoud; Ferdowsi University of Mashhad. Faculty of Sciences. Deptartment of Biology. Mashhad. IR
  • Khodabandehloo, Fatimeh; AJA University of Medical Sciences. School of Medicine. Department of Physiology. Tehran. IR
Arq. neuropsiquiatr ; 70(6): 447-452, June 2012. graf
Article in English | LILACS | ID: lil-626286
Responsible library: BR1.1
ABSTRACT
Different effects of scopolamine on learning, memory, and nitric oxide (NO) metabolites in hippocampal tissues of ovariectomized (OVX) and sham-operated rats were investigated. The animals in the Sham-Scopolamine (Sham-Sco) and OVX-Scopolamine (OVX-Sco) Groups were treated with 2 mg/kg scopolamine before undergoing the Morris water maze, while the animals in the Sham and OVX Groups received saline. The time latency and path length were significantly higher in both the Sham-Sco and the OVX-Sco Groups, in comparison with the Sham and OVX Groups, respectively (p<0.001). Significantly lower NO metabolite levels in the hippocampi of the Sham-Sco Group were observed, compared with the Sham Group (p<0.001), while there was no significant difference between the OVX-Sco and OVX Groups. The decreased NO level in the hippocampus may play a role in the learning and memory deficits induced by scopolamine. However, it seems that the effect of scopolamine on hippocampal NO differs between situations of presence and absence of ovarian hormones.
RESUMO
Diferentes efeitos da escopolamina no aprendizado, na memória e nos níveis dos metabólitos do óxido nítrico (ON) no tecido hipocampal de ratas ovariectomizadas (OVX) e controles com cirurgia sem ooforectomia (Grupo Sham) foram investigados. Os animais dos grupos Sham-Escopolamina (Sham-Sco) e OVX-Escopolamina (OVX-Sco) foram tratados com escopolamina 2 mg/kg antes de entrar no labirinto aquático de Morris, enquanto aqueles dos grupos Sham e OVX receberam solução salina. A latência de tempo e o comprimento do caminho foram significativamente maiores nos Grupos Sham-Sco e OVX-Sco em comparação com os grupos Sham e OVX, respectivamente (p<0,001). Foram observados níveis significativamente mais baixos de metabólitos do ON nos hipocampos do Grupo Sham-Sco em comparação aos níveis do Sham (p<0,001), enquanto não foi observada diferença significativa entre os Grupos OVX-Sco e OVX. A diminuição do nível de ON no hipocampo pode ter um papel no aprendizado e nos déficits de memória induzidos pela escopolamina. No entanto, parece que este efeito da escopolamina no ON hipocampal é diferente em situações de presença ou ausência de hormônios ovarianos.
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Full text: Available Index: LILACS (Americas) Main subject: Scopolamine / Maze Learning / Cholinergic Antagonists / Hippocampus / Memory / Nitric Oxide Limits: Animals Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2012 Type: Article Affiliation country: Iran Institution/Affiliation country: AJA University of Medical Sciences/IR / Ferdowsi University of Mashhad/IR / Islamic Azad University, Khorasgan Branch/IR / Mashhad University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Scopolamine / Maze Learning / Cholinergic Antagonists / Hippocampus / Memory / Nitric Oxide Limits: Animals Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2012 Type: Article Affiliation country: Iran Institution/Affiliation country: AJA University of Medical Sciences/IR / Ferdowsi University of Mashhad/IR / Islamic Azad University, Khorasgan Branch/IR / Mashhad University of Medical Sciences/IR