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Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease
Souza, João Antonio Chaves de; Junior, Carlos Rossa; Garlet, Gustavo Pompermaier; Nogueira, Andressa Vilas Boas; Cirelli, Joni Augusto.
  • Souza, João Antonio Chaves de; UNESP. School of Dentistry. Department of Diagnosis and Surgery. Araraquara. BR
  • Junior, Carlos Rossa; UNESP. School of Dentistry. Department of Diagnosis and Surgery. Araraquara. BR
  • Garlet, Gustavo Pompermaier; University of São Paulo. Department of Biological Sciences, Bauru School of Dentistry. Bauru. BR
  • Nogueira, Andressa Vilas Boas; UNESP. School of Dentistry. Department of Diagnosis and Surgery. Araraquara. BR
  • Cirelli, Joni Augusto; UNESP. School of Dentistry. Department of Diagnosis and Surgery. Araraquara. BR
J. appl. oral sci ; 20(2): 128-138, Mar.-Apr. 2012. ilus, tab
Article in English | LILACS | ID: lil-626410
Responsible library: BR1.1
ABSTRACT
Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies for inhibiting signal transduction pathways involved in inflammation. Pharmacological inhibitors of MAPK, NFκB and JAK/STAT pathways are being developed to manage rheumatoid arthritis, periodontal disease and other inflammatory diseases. Through these agents, inflammatory mediators can be inhibited at cell signaling level, interfering on transcription factors activation and inflammatory gene expression. Although these drugs offer great potential to modulate host response, their main limitations are lack of specificity and developments of side effects. After overcoming these limitations, adjunctive host modulating drugs will provide new therapeutic strategies for periodontal treatment.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Periodontal Diseases / Signal Transduction / Inflammation Mediators / Intracellular Signaling Peptides and Proteins / Molecular Targeted Therapy Limits: Humans Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2012 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: UNESP/BR / University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Periodontal Diseases / Signal Transduction / Inflammation Mediators / Intracellular Signaling Peptides and Proteins / Molecular Targeted Therapy Limits: Humans Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2012 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: UNESP/BR / University of São Paulo/BR