Differential expression of salivary glycoproteins in aggressive and chronic periodontitis
J. appl. oral sci
;
20(2): 180-185, Mar.-Apr. 2012. ilus
Article
in English
| LILACS
| ID: lil-626418
ABSTRACT
OBJECTIVES:
The aim of this study was to compare the pattern of secretion and the expression of mucin glycoprotein-2 (MG2) and lactoferrin in individuals with or without periodontitis. MATERIAL ANDMETHODS:
Five individuals with aggressive periodontitis (APG), 5 with generalized chronic periodontitis (CPG) and 5 without periodontitis (CG) were enrolled after informed consent. Non-stimulated and stimulated submandibular and sublingual saliva was collected and samples analyzed by Western blot probed with specific antibodies.RESULTS:
Stimulated and non-stimulated salivary flow rates did not differ among groups. Western blot analysis revealed that stimulation led to an increase in MG2 expression in all groups, and to lactoferrin expression in APG and CPG. In non-stimulated saliva, CG exhibited the highest expression of both glycoproteins. In stimulated saliva, CG exhibited the highest expression of MG2, whereas APG the highest of lactoferrin.CONCLUSIONS:
The pattern of secretion of MG2 and lactoferrin in health and disease is complex. Although the present study analyzed samples from a limited number of participants, the reduced expression of MG2 and lactoferrin in APG and CPG under non-stimulated condition, the predominant circumstance of salivary secretion during the day, suggests that these salivary constituents may play a role in the etiopathogenesis of these diseases.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Aggressive Periodontitis
/
Saliva
/
Salivary Glands
/
Chronic Periodontitis
/
Lactoferrin
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2012
Type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Boston University/US
/
Pontifical Catholic University of Minas Gerais/BR
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