Effect of obesity on alveolar bone loss in experimental periodontitis in Wistar rats
J. appl. oral sci
;
20(2): 218-221, Mar.-Apr. 2012. tab
Article
in English
| LILACS
| ID: lil-626424
ABSTRACT
Obesity has been linked to higher inflammatory status and periodontal breakdown. OBJECTIVE:
The purpose of this study was to investigate the effect of obesity on alveolar bone loss in experimental periodontitis in rats. MATERIAL ANDMETHODS:
Twenty-four female Wistar rats were randomly divided into two groups obese (n=13), which were fed with "cafeteria diet" (CAF diet - high amounts of sucrose and fat) for 90 days in order to gain weight, and non-obese (n=11) regularly fed rats. Ligature-induced experimental periodontitis was created in all animals. Body weight differed statistically between obese and non-obese groups (277.59 and 223.35 g, respectively) at the moment of the ligature placement. Morphometric registration of alveolar bone loss was carried out after 30 days of ligature placement to determine the effect of obesity on the progression of experimental periodontitis.RESULTS:
Intra-group comparisons showed significantly higher alveolar bone loss mean values in maxillary teeth with ligature (P<0.05). Alveolar bone loss [mean (SD), mm] was not statistically different between obese and non-obese groups [0.71 (0.09) and 0.65 (0.07) mm, respectively]. However, when palatal sides are analyzed separately, obese group presented significantly higher alveolar bone loss (P<0.05) as compared to non-obese [0.68 (0.12) and 0.53 (0.13) mm, respectively].CONCLUSIONS:
In spite of the weak differences, it is possible to conclude that the progression of alveolar bone loss in ligature-induced periodontitis can be potentially influenced by body weight in rats.
Full text:
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Index:
LILACS (Americas)
Main subject:
Periodontitis
/
Alveolar Bone Loss
/
Obesity
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Rio Grande do Sul/BR
/
Lutheran University of Brazil/BR
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