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Helicobacter pylori vacA and cagA genotypes in patients from northeastern Brazil with upper gastrointestinal diseases
Cavalcante, Meyssa Quezado de Figueiredo; Silva, Cicero Igor Simões; Braga-Neto, Manuel Bonfim; Fialho, Andréa Bessa Campelo; Nunes Fialho, André; Barbosa, Alzira Maria C; Cruz, Francisco Will Saraiva; Rocha, Gifone A; Queiroz, Dulciene Maria Magalhães de; Braga, Lucia Libanez Bessa Campelo.
  • Cavalcante, Meyssa Quezado de Figueiredo; Universidade Federal do Ceará. Unidade de Pesquisas Clínicas. Fortaleza. BR
  • Silva, Cicero Igor Simões; Universidade Federal do Ceará. Unidade de Pesquisas Clínicas. Fortaleza. BR
  • Braga-Neto, Manuel Bonfim; Universidade Federal do Ceará. Unidade de Pesquisas Clínicas. Fortaleza. BR
  • Fialho, Andréa Bessa Campelo; Universidade Federal do Ceará. Unidade de Pesquisas Clínicas. Fortaleza. BR
  • Nunes Fialho, André; Universidade Federal do Ceará. Unidade de Pesquisas Clínicas. Fortaleza. BR
  • Barbosa, Alzira Maria C; Universidade Federal do Ceará. Unidade de Pesquisas Clínicas. Fortaleza. BR
  • Cruz, Francisco Will Saraiva; Universidade Federal do Ceará. Unidade de Pesquisas Clínicas. Fortaleza. BR
  • Rocha, Gifone A; Universidade Federal de Minas Gerais. Laboratório de Pesquisas em Bacteriologia. Belo Horizonte. BR
  • Queiroz, Dulciene Maria Magalhães de; Universidade Federal de Minas Gerais. Laboratório de Pesquisas em Bacteriologia. Belo Horizonte. BR
  • Braga, Lucia Libanez Bessa Campelo; Universidade Federal do Ceará. Unidade de Pesquisas Clínicas. Fortaleza. BR
Mem. Inst. Oswaldo Cruz ; 107(4): 561-563, June 2012. tab
Article in English | LILACS | ID: lil-626455
ABSTRACT
Helicobacter pylori causes chronic gastric inflammation and significantly increases the risk of duodenal and gastric ulcer disease and distal gastric carcinoma. In this study, we evaluated the Helicobacter pylori vacA and cagA genotypes in patients from a Brazilian region where there is a high prevalence of gastric cancer. Polymerase chain reaction (PCR) was used to investigate vacA mosaicism and cagA status in the gastric mucosa of 134 H. pylori-positive patients, including 76 with gastritis 28 with peptic ulcer disease and 30 with gastric cancer. The s1m1 variant was the predominant vacA genotype observed, whereas the s1 allele was more frequently observed in patients with more severe diseases associated with H. pylori infection [p = 0.03, odds ratio (OR) = 5.72, 95% confidence interval (CI) = 1.15-38.60]. Furthermore, all of the s1 alleles were s1b. Mixed vacA m1/m2 strains were found more frequently in patients with gastric cancer and a cagA-positive status was significantly associated with gastric cancer (p = 0.016, OR = 10.36, 95% CI = 1.35-217.31). Patients with gastric cancer (21/21, 100%, p = 0.006) or peptic ulcers (20/21, 95%, p = 0.02) were more frequently colonised by more virulent H. pylori strains compared to gastritis patients (41/61, 67.2%). In conclusion, in the northeastern of Brazil, which is one of the regions with the highest prevalence of gastric cancer in the country, infection with the most virulent H. pylori strains, carrying the cagA gene and s1m1 vacA alleles, predominates and is correlated with more severe H. pylori-associated diseases.
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Full text: Available Index: LILACS (Americas) Main subject: Bacterial Proteins / Helicobacter pylori / Helicobacter Infections / Antigens, Bacterial Type of study: Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR / Universidade Federal do Ceará/BR

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Full text: Available Index: LILACS (Americas) Main subject: Bacterial Proteins / Helicobacter pylori / Helicobacter Infections / Antigens, Bacterial Type of study: Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR / Universidade Federal do Ceará/BR