E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma
Rev. clín. periodoncia implantol. rehabil. oral (Impr.)
;
4(3): 122-125, dic. 2011. ilus
Article
in English
| LILACS
| ID: lil-627549
ABSTRACT
Objective:
The aim of this study was to assess epithelial expression of E-cadherin and c-Met in normal lip, in actinic cheilitis and lip squamous cell carcinoma. StudyDesign:
Biopsies of normal lip vermillion (NL, n=18), actinic cheilitis (AC, n=37), and lip SCC (n=22) were processed for E-cadherin and c-Met immunodetection. Epithelial and tumor cell expression was scored for each sample considering staining intensity and percentage.Results:
E-cadherin expression was significantly reduced in AC and lip SCC as compared to normal lip (P<0.05), with a significant reduction in lip SCC as compared to AC (P=0.003). Expression of c-Met was significantly higher in AC and lip SCC as compared to NL (P<0.05), with a significant increase in lip SCC as compared to AC (P<0.0001).Conclusion:
The results showed that epithelial E-cadherin expression is reduced and c-Met expression is increased as lip carcinogenesis progresses, suggesting that these proteins may be useful markers of malignant transformation.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Lip Neoplasms
/
Carcinoma, Squamous Cell
/
Cadherins
/
Cheilitis
/
Proto-Oncogene Proteins c-met
Limits:
Humans
Language:
English
Journal:
Rev. clín. periodoncia implantol. rehabil. oral (Impr.)
Journal subject:
Dentistry
Year:
2011
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
University of Concepción/CL
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