Niveles séricos del antígeno prostático específico en varones expuestos y no expuestos al arsénico en el agua de bebida en Tucumán, Argentina / Total prostatic specific antigen levels among subjects exposed and not exposed to arsenic in drinking water
Rev. méd. Chile
;
139(12): 1581-1587, dic. 2011. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-627592
ABSTRACT
Background:
There is an association between arsenic exposure and prostatic cancer mortality.Aim:
To analyze and to compare the serum levels of total prostatic specific antigen (TPSA) in asymptomatic men of a rural zone, exposed and not exposed to high concentrations of arsenic (As) in drinking water. Material andMethods:
The study included 161 men that were subjected to a clinical evaluation, serum TPSA determination and a trans rectal ultrasonography. Exposed and non-exposed subjects were divided in groups GA, GB and GC according to TPSA levels (<4 ng/ml, 4.1-10 ng/ml and >10.1 ng/ml respectively).Results:
Exposed and non-exposed subjects had similar TPSA levels. Among exposed subjects, 88.2, 8,8 and 3% were ascribed to groups GA, GB and GC respectively. The figures for non-exposed subjects were 90. 6, 6,3 and 3,1%. The area under the receiver operating characteristic (ROC) curve for TPSA in exposed and non-exposed subjects was 0.64 (95% confidence intervals (CI) 0.40-0.9) and 0.71 (95% CI 0.6-0.8) respectively.Conclusions:
No differences in TPSA levels between subjects exposed and non-exposed to arsenic were observed in this study.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Prostatic Neoplasms
/
Drinking Water
/
Prostate-Specific Antigen
/
Arsenic Poisoning
/
Environmental Exposure
Type of study:
Prognostic study
Limits:
Humans
/
Male
Country/Region as subject:
South America
/
Argentina
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2011
Type:
Article
/
Project document
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad Nacional de Tucumán/AR
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