Niveles séricos de metaloproteinasa 9 (mmp-9) y del inhibidor tisular de mmp tipo 1 (timp-1) en pacientes venezolanos con asma o con enfermedad pulmonar obstructiva crónica (epoc) / Serum metalloproteinase 9 (MMP-9) and tissue inhibitor of MMP-1 (TIMP-1) in venezuelan patients with asthma or chronic obstructive pulmonary disease (copd)
Rev. Fac. Med. (Caracas)
;
33(1): 6-10, jun. 2010. tab
Article
in Spanish
| LILACS
| ID: lil-631573
RESUMEN
Los niveles séricos de la metaloproteinasa (MMP) 9, enzima involucrada en inflamación, y su contraparte, el inhibidor tisular de la metaloproteinasas tipo 1 (TIMP-1), se encuentran significativamente (P < 0,01) incrementados en pacientes con asma o con enfermedad pulmonar obstructiva crónica (EPOC) en comparación con los grupos control del mismo rango etario. El incremento de ambos parámetros se hace más significativo en los pacientes severos de ambos grupos (P < 0,0001) y particularmente en los pacientes con EPOC severo en comparación con los asmáticos severos (P < 0,01). El incremento en los niveles séricos de MMP-9 en relación con severidad es mayor que lo observado para TIMP-1 en ambas patologías. Se concluye que los niveles séricos de MMP-9 y TIMP-1 pueden ser un marcador importante para determinar severidad en estas enfermedades
ABSTRACT
Serum levels of metalloproteinase (MMP) 9, an enzyme involved in inflammation, and its counterpart, the tissue inhibitor of metalloproteinases type 1 (TIMP-1) are significantly (P < 0.01) increased in patients with asthma or with chronic obstructive pulmonary disease (COPD) as compared with controls of the same age. The increase in both parameters is more significant (P < 0.0001) in severe patients of both groups, and particularly in patients with severe COPD as compared to severe asthmatics (P < 0.01). The increase in serum MMP-9 levels in relation with severity is higher than the observed values for TIMP-1 in both diseases. It is concluded that serum levels of MMP-9 and TIMP-1 may be important markers to establish severity in these diseases
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Asthma
/
Biomarkers
/
Tissue Inhibitor of Metalloproteinase-1
/
Matrix Metalloproteinase 9
/
Pulmonary Disease, Chronic Obstructive
Type of study:
Evaluation studies
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Venezuela
Language:
Spanish
Journal:
Rev. Fac. Med. (Caracas)
Journal subject:
Medicine
Year:
2010
Type:
Article
Affiliation country:
Venezuela
Institution/Affiliation country:
Universidad Central de Venezuela/VE
Similar
MEDLINE
...
LILACS
LIS